Leather cable cable connector protection box, including the upper cover, lower cover and clip structure, the upper cover and the lower cover contact surface is provided with a sealing slot, sealing slot is provided with a sealing strip, the protection box is provided with a cable hole, the cable hole is embedded with a sealing ring, through the sealing strip and the sealing slot and the sealing ring with the cable hole, improve the sealing performance of the protection box, Prevent dust and mosquitoes from entering the protective box and eroding the connectors of the optical cable.